The Potentials of Methylene Blue as an Anti-Aging Drug

The article discusses the role of Methylene Blue (MB) in skin aging and wound healing. The skin, as a complex organ, is composed of three layers: the epidermis, dermis, and subcutis. Aging affects the skin by causing loss of elasticity, thinning, and atrophy of the extracellular matrix (ECM), predominantly due to reactive oxygen species (ROS). There are two types of skin aging: intrinsic, related to natural physiological changes, and extrinsic, often accelerated by environmental factors like UV radiation. Both types involve oxidative stress, leading to decreased collagen synthesis and increased breakdown, thus accelerating aging.

MB has been identified as a potent antioxidant effective against ROS, which helps in mitigating cellular oxidative damages, stimulating skin proliferation, and promoting wound healing. It has been found to outperform common skincare antioxidants like vitamin C and retinol in promoting cell proliferation and reducing aging markers. Furthermore, MB treatment stimulates the expression of ECM proteins, enhancing skin thickness and hydration, and provides broad-spectrum UV ray absorption.

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